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Cardiovascular

Evolocumab

Repatha®

Evolocumab is a PCSK9 inhibitor monoclonal antibody that dramatically lowers LDL cholesterol. Used in familial hypercholesterolemia and established ASCVD.

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Product Details

Dosage FormSC Injectable (Prefilled Syringe / Autoinjector)
Strength140 mg/mL; 420 mg/3.5mL
StorageStore at 2–8°C. May be stored at room temperature (up to 25°C) for up to 30 days.
CategoryCardiovascular
AvailabilityAvailable for Transfer

Indication

Primary hyperlipidemia; HoFH; established ASCVD to reduce cardiovascular events.

Mechanism of Action

Fully human IgG2 monoclonal antibody that binds to PCSK9, preventing PCSK9-mediated LDL receptor degradation. This increases hepatic LDL receptor availability and clearance of LDL-C.

Technology Transfer Package

Each Burrard Pharmaceuticals technology transfer package for Evolocumab includes comprehensive documentation and support:

Master Formula

Complete formulation with manufacturing parameters, excipient specifications, and process controls.

Analytical Methods

Validated methods for assay, impurities, dissolution, and stability-indicating analysis.

CTD/eCTD Templates

Market-ready regulatory dossier templates — available through Burrard Intelligence subscription.

Stability Data

ICH-compliant stability studies (accelerated and long-term) with detailed protocols.

Manufacturing Protocols

Scale-up procedures, batch records, equipment specifications, and in-process controls.

Expert Support

Direct advisory access to formulation scientists and regulatory specialists throughout transfer.

Ready for Evolocumab Technology Transfer?

Our team can deliver the complete know-how package within 2–21 business days. Book a consultation to discuss your specific requirements.

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