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Ophthalmics

Aflibercept

Eylea®

Aflibercept is a recombinant fusion protein that acts as a soluble decoy receptor for VEGF-A, VEGF-B, and PlGF. It is the most widely used intravitreal anti-VEGF agent.

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Product Details

Dosage FormIntravitreal Injection (Solution)
Strength2 mg/0.05mL; 8 mg/0.07mL (Eylea HD)
StorageStore at 2–8°C. Protect from light. Do not freeze.
CategoryOphthalmics
AvailabilityAvailable for Transfer

Indication

Wet age-related macular degeneration (AMD); diabetic macular edema (DME); macular edema following retinal vein occlusion (RVO); diabetic retinopathy; retinopathy of prematurity.

Mechanism of Action

Fusion protein combining VEGF receptor 1 and 2 extracellular domains with human IgG1 Fc. Binds VEGF-A, VEGF-B, and PlGF with higher affinity than native receptors, preventing neovascularization and vascular permeability.

Technology Transfer Package

Each Burrard Pharmaceuticals technology transfer package for Aflibercept includes comprehensive documentation and support:

Master Formula

Complete formulation with manufacturing parameters, excipient specifications, and process controls.

Analytical Methods

Validated methods for assay, impurities, dissolution, and stability-indicating analysis.

CTD/eCTD Templates

Market-ready regulatory dossier templates — available through Burrard Intelligence subscription.

Stability Data

ICH-compliant stability studies (accelerated and long-term) with detailed protocols.

Manufacturing Protocols

Scale-up procedures, batch records, equipment specifications, and in-process controls.

Expert Support

Direct advisory access to formulation scientists and regulatory specialists throughout transfer.

Ready for Aflibercept Technology Transfer?

Our team can deliver the complete know-how package within 2–21 business days. Book a consultation to discuss your specific requirements.

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